4′-Phosphopantetheine Biosynthesis in Archaea
نویسندگان
چکیده
منابع مشابه
4'-phosphopantetheine and coenzyme A biosynthesis in plants.
Coenzyme A is required for many synthetic and degradative reactions in intermediary metabolism and is the principal acyl carrier in prokaryotic and eukaryotic cells. Coenzyme A is synthesized in five steps from pantothenate, and recently the CoaA biosynthetic genes in bacteria and human have all been identified and characterized. Coenzyme A biosynthesis in plants is not fully understood, and to...
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CoA is a ubiquitous molecule in all three domains of life and is involved in various metabolic pathways. The enzymes and reactions involved in CoA biosynthesis in eukaryotes and bacteria have been identified. By contrast, the proteins/genes involved in CoA biosynthesis in archaea have not been fully clarified, and much has to be learned before we obtain a general understanding of how this molec...
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The hypothetical protein predicted by the open reading frame MJ0055 of Methanococcus jannaschii was expressed in a recombinant Escherichia coli strain under the control of a synthetic gene optimized for translation in an eubacterial host. The recombinant protein catalyzes the formation of the riboflavin precursor 3,4-dihydroxy-2-butanone 4-phosphate from ribulose 5-phosphate at a rate of 174 nm...
متن کاملProtein turnover and 4'-phosphopantetheine exchange in rat liver fatty acid synthetase.
The rate of turnover of rat liver fatty acid synthetase has been measured in animals tested under steady state conditions. The value obtained for the half-life varied from 71 to 108 hours. The exchange rate of the covalently bound prosthetic group, 4’-phosphopantotheine, with unbound pantothenate compounds was found to be more than an order of magnitude greater than the half-life of the enzyme ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2006
ISSN: 0021-9258
DOI: 10.1074/jbc.m510056200